5FV1

Crystal structure of hVEGF in complex with VK domain antibody

Summary for 5FV1

Entry DOI	10.2210/pdb5fv1/pdb
Related	5FV2
Descriptor	VK DOMAIN ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR A (3 entities in total)
Functional Keywords	immune system, vegf, domain antibody, vascular endothelial growth factor
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	51183.96
Authors	Chung, C.,Walker, A. (deposition date: 2016-02-02, release date: 2016-02-17, Last modification date: 2019-05-15)
Primary citation	Walker, A.,Chung, C.,Neu, M.,Burman, M.,Batuwangala, T.,Jones, G.,Tang, C.,Steward, M.,Mullin, M.,Tournier, N.,Lewis, A.,Korczynska, J.,Chung, V.,Catchpole, I. Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept. J.Biol.Chem., 291:5500-, 2016 Cited by PubMed: 26728464 DOI: 10.1074/JBC.M115.691162 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation