5FV1

Crystal structure of hVEGF in complex with VK domain antibody

5FV1 の概要

• エントリーDOI: 10.2210/pdb5fv1/pdb
• 関連するPDBエントリー: 5FV2
• 分子名称: VK DOMAIN ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR A (3 entities in total)
• 機能のキーワード: immune system, vegf, domain antibody, vascular endothelial growth factor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 51183.96

構造登録者

Chung, C.,Walker, A. (登録日: 2016-02-02, 公開日: 2016-02-17, 最終更新日: 2019-05-15)

• 主引用文献: Walker, A.,Chung, C.,Neu, M.,Burman, M.,Batuwangala, T.,Jones, G.,Tang, C.,Steward, M.,Mullin, M.,Tournier, N.,Lewis, A.,Korczynska, J.,Chung, V.,Catchpole, I.; Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.; J.Biol.Chem., 291:5500-, 2016; PubMed: 26728464; DOI: 10.1074/JBC.M115.691162

実験手法

X-RAY DIFFRACTION (2.7 Å)