5FUN

Crystal structure of human JARID1B in complex with GSK467

Summary for 5FUN

Entry DOI	10.2210/pdb5fun/pdb
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 2-[(1-benzyl-1H-pyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4(3H)-one, ... (9 entities in total)
Functional Keywords	oxidoreductase, lysine-specific demethylase 5b
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9UGL1
Total number of polymer chains	1
Total formula weight	56567.19
Authors	Srikannathasan, V.,Johansson, C.,Gileadi, C.,Kopec, J.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Brennan, P.,Oppermann, U. (deposition date: 2016-01-28, release date: 2016-04-13, Last modification date: 2024-01-10)
Primary citation	Johansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U. Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12:539-, 2016 Cited by PubMed: 27214403 DOI: 10.1038/NCHEMBIO.2087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation