5FUN
Crystal structure of human JARID1B in complex with GSK467
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1754 |
| Chain | Residue |
| A | CYS692 |
| A | CYS695 |
| A | CYS715 |
| A | HIS718 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1755 |
| Chain | Residue |
| A | CYS706 |
| A | CYS708 |
| A | CYS723 |
| A | CYS725 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GZA A 1756 |
| Chain | Residue |
| A | TYR425 |
| A | TYR488 |
| A | SER495 |
| A | PHE496 |
| A | HIS499 |
| A | ASN509 |
| A | LYS517 |
| A | TRP519 |
| A | HIS587 |
| A | MN1757 |
| A | HOH2079 |
| A | HOH2086 |
| A | HOH2090 |
| A | HOH2166 |
| A | ARG86 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1757 |
| Chain | Residue |
| A | HIS499 |
| A | GLU501 |
| A | HIS587 |
| A | GZA1756 |
| A | HOH2079 |
| A | HOH2086 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 1758 |
| Chain | Residue |
| A | LEU90 |
| A | ASN91 |
| A | LEU413 |
| A | THR416 |
| A | GLU419 |
| A | HOH2023 |
| A | HOH2025 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1759 |
| Chain | Residue |
| A | HIS622 |
| A | LYS694 |
| A | HIS718 |
| A | HOH2116 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE EPE A 1760 |
| Chain | Residue |
| A | ILE500 |
| A | TRP504 |
| A | MET534 |
| A | LEU541 |
| A | LEU552 |
| A | ARG584 |
| A | HIS617 |
| A | TYR618 |
| A | LEU621 |
| A | ARG623 |
| A | HOH2075 |
| A | HOH2084 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1761 |
| Chain | Residue |
| A | ILE475 |
| A | ALA477 |
| A | PHE627 |
| A | SER628 |
| A | GLU631 |
| A | MET632 |
| A | HOH2147 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1762 |
| Chain | Residue |
| A | ASP688 |
| A | GLU689 |
| A | ARG690 |
| A | GLN691 |
| A | VAL693 |
| A | GLY711 |
| A | LEU712 |
| A | LEU713 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1763 |
| Chain | Residue |
| A | ARG670 |
| A | VAL674 |
| A | ILE675 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1764 |
| Chain | Residue |
| A | ALA386 |
| A | ASP387 |
| A | LYS390 |
| A | MET491 |
| A | CYS492 |
| A | GLU515 |
| A | GLY593 |
| A | PHE594 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
