5FRM

Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and the INSTI XZ384 (compound 4a)

5FRM の概要

• エントリーDOI: 10.2210/pdb5frm/pdb
• 関連するPDBエントリー: 5FRN 5FRO
• 分子名称: PFV INTEGRASE, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP *TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP *AP*CP*A)-3', ... (10 entities in total)
• 機能のキーワード: recombination, viral protein/dna, protein-dna complex, tetramer, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna- binding, zinc binding, hhcc motif, viral protein, inhibitor, dna-binding protein-dna complex
• 由来する生物種: HUMAN SPUMARETROVIRUS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101816.19

構造登録者

Maskell, D.P.,Pye, V.E.,Cherepanov, P. (登録日: 2015-12-18, 公開日: 2016-02-17, 最終更新日: 2024-01-10)

• 主引用文献: Zhao, X.Z.,Smith, S.J.,Maskell, D.P.,Metifiot, M.,Pye, V.E.,Fesen, K.,Marchand, C.,Pommier, Y.,Cherepanov, P.,Hughes, S.H.,Burke, T.R.J.; HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases.; Acs Chem.Biol., 11:1074-, 2016; PubMed: 26808478; DOI: 10.1021/ACSCHEMBIO.5B00948

実験手法

X-RAY DIFFRACTION (2.58 Å)