5FPQ

Structure of Homo sapiens acetylcholinesterase phosphonylated by sarin.

Summary for 5FPQ

Entry DOI	10.2210/pdb5fpq/pdb
Related	5FOQ 5FPP
Descriptor	ACETYLCHOLINESTERASE, PENTAETHYLENE GLYCOL (3 entities in total)
Functional Keywords	hydrolase, signaling protein, acetylcholinesterase, sarin, hi-6, qm, density functional theory calculations, michaelis complex.
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell junction, synapse . Isoform T: Nucleus. Isoform H: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side : P22303
Total number of polymer chains	2
Total formula weight	119372.66
Authors	Allgardsson, A.,Berg, L.,Akfur, C.,Hornberg, A.,Worek, F.,Linusson, A.,Ekstrom, F. (deposition date: 2015-12-02, release date: 2016-05-11, Last modification date: 2024-01-10)
Primary citation	Allgardsson, A.,Berg, L.,Akfur, C.,Hornberg, A.,Worek, F.,Linusson, A.,Ekstrom, F.J. Structure of a Prereaction Complex between the Nerve Agent Sarin, its Biological Target Acetylcholinesterase, and the Antidote Hi-6. Proc.Natl.Acad.Sci.USA, 113:5514-, 2016 Cited by PubMed: 27140636 DOI: 10.1073/PNAS.1523362113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation