5FPL
Crystal structure of human JARID1B in complex with CCT363901
Summary for 5FPL
Entry DOI | 10.2210/pdb5fpl/pdb |
Related | 5FPU 5FPV |
Descriptor | LYSINE-SPECIFIC DEMETHYLASE 5B, LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ... (7 entities in total) |
Functional Keywords | oxidoreductase, lysine-specific demethylase 5b |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q9UGL1 |
Total number of polymer chains | 1 |
Total formula weight | 56004.39 |
Authors | Srikannathasan, V.,Yann-Vai, L.B.,Nowak, R.,Johansson, C.,Gileadi, C.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Brennan, P.,Huber, K.,Oppermann, U. (deposition date: 2015-12-02, release date: 2016-01-20, Last modification date: 2024-01-10) |
Primary citation | Bavetsias, V.,Lanigan, R.M.,Ruda, G.F.,Atrash, B.,Mclaughlin, M.G.,Tumber, A.,Mok, N.Y.,Le Bihan, Y.,Dempster, S.,Boxall, K.J.,Jeganathan, F.,Hatch, S.B.,Savitsky, P.,Velupillai, S.,Krojer, T.,England, K.S.,Sejberg, J.,Thai, C.,Donovan, A.,Pal, A.,Scozzafava, G.,Bennett, J.M.,Kawamura, A.,Johansson, C.,Szykowska, A.,Gileadi, C.,Burgess-Brown, N.A.,von Delft, F.,Oppermann, U.,Walters, Z.,Shipley, J.,Raynaud, F.I.,Westaway, S.M.,Prinjha, R.K.,Fedorov, O.,Burke, R.,Schofield, C.J.,Westwood, I.M.,Bountra, C.,Muller, S.,Van Montfort, R.L.M.,Brennan, P.E.,Blagg, J. 8-Substituted Pyrido[3,4-D]Pyrimidin-4(3H)-One Derivatives as Potent, Cell Permeable, Kdm4 (Jmjd2) and Kdm5 (Jarid1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59:1388-, 2016 Cited by PubMed: 26741168DOI: 10.1021/ACS.JMEDCHEM.5B01635 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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