5FOB

Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)

Summary for 5FOB

Related5FO7 5FO8 5FO9 5FOA
DescriptorCOMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, D15L, ... (11 entities in total)
Functional Keywordslipid binding protein, complement system, immune system, plasma protein, regulators of complement activity, cofactor activity, decay accelerating activity, immune evasion
Biological sourceVARIOLA MAJOR VIRUS
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Cellular locationSecreted P01024 Q76U65
Total number of polymer chains3
Total molecular weight206886.66
Authors
Forneris, F.,Wu, J.,Xue, X.,Gros, P. (deposition date: 2015-11-18, release date: 2016-04-06, Last modification date: 2016-06-01)
Primary citation
Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P.
Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35:1133-, 2016
PubMed: 27013439 (PDB entries with the same primary citation)
DOI: 10.15252/EMBJ.201593673
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23490.7%11.8%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution