5FOB

Crystal Structure of Human Complement C3b in complex with Smallpox Inhibitor of Complement (SPICE)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	COMPLEMENT C3 BETA CHAIN	polymer	645	71393.3	1	UniProt (P01024) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) In PDB	HOMO SAPIENS (HUMAN)	C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 1
2	B	COMPLEMENT C3B ALPHA' CHAIN	polymer	915	104074.1	1	UniProt (P01024) Pfam (PF07677) Pfam (PF01759) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308) In PDB	HOMO SAPIENS (HUMAN)
3	C	SMALLPOX INHIBITOR OF COMPLEMENT SPICE, D15L	polymer	245	26868.2	1	UniProt (Q76U65) Pfam (PF00084) In PDB	VARIOLA MAJOR VIRUS
4	D	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	1	In PDB GlyTouCan (G32152BH)
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A, B, C	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
7	B, A, C	GLYCEROL	non-polymer		92.1	24	Chemie (GOL)
8	B, A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
9	B, A	IODIDE ION	non-polymer		126.9	7	Chemie (IOD)
10		water	water		18.0	207	Chemie (HOH)

Sequence modifications

B: 749 - 1663 (UniProt: P01024)

PDB	External Database	Details
Glu 1013	Gln 1013	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	202335.7
Branched	Number of molecules	2
	Total formula weight	1157.1
Non-Polymers*	Number of molecules	38
	Total formula weight	3321.8
All*	Total formula weight	206814.6

*Water molecules are not included.