5FND

Dynamic Undocking and the Quasi-Bound State as tools for Drug Design

Summary for 5FND

• Entry DOI: 10.2210/pdb5fnd/pdb
• Related: 5FNC 5FNF
• Descriptor: HEAT SHOCK PROTEIN, HSP90-ALPHA, N-(2-AZANYL-6-METHYL-1,3-BENZOTHIAZOL-5-YL)ETHANAMIDE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hsp90, drug design, chaperone, oncology
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 27015.18

Authors

Ruiz-Carmona, S.,Schmidtke, P.,Luque, F.J.,Baker, L.M.,Matassova, N.,Davis, B.,Roughley, S.,Murray, J.,Hubbard, R.,Barril, X. (deposition date: 2015-11-13, release date: 2016-11-23, Last modification date: 2024-01-10)

• Primary citation: Ruiz-Carmona, S.,Schmidtke, P.,Luque, F.J.,Baker, L.,Matassova, N.,Davis, B.,Roughley, S.,Murray, J.,Hubbard, R.,Barril, X.; Dynamic undocking and the quasi-bound state as tools for drug discovery.; Nat Chem, 9:201-206, 2017; PubMed: 28221352; DOI: 10.1038/nchem.2660

Experimental method

X-RAY DIFFRACTION (2 Å)