5FNF
Dynamic Undocking and the Quasi-Bound State as tools for Drug Design
Summary for 5FNF
Entry DOI | 10.2210/pdb5fnf/pdb |
Related | 5FNC 5FND |
Descriptor | HEAT SHOCK PROTEIN, HSP90-ALPHA, SULFATE ION, 4-[(E)-N-oxidanyl-C-pyridin-3-yl-carbonimidoyl]benzene-1,3-diol, ... (4 entities in total) |
Functional Keywords | hsp90, drug design, chaperone, oncology |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 27024.12 |
Authors | Ruiz-Carmona, S.,Schmidtke, P.,Luque, F.J.,Baker, L.M.,Matassova, N.,Davis, B.,Roughley, S.,Murray, J.,Hubbard, R.,Barril, X. (deposition date: 2015-11-13, release date: 2016-11-23, Last modification date: 2024-01-10) |
Primary citation | Ruiz-Carmona, S.,Schmidtke, P.,Luque, F.J.,Baker, L.,Matassova, N.,Davis, B.,Roughley, S.,Murray, J.,Hubbard, R.,Barril, X. Dynamic undocking and the quasi-bound state as tools for drug discovery. Nat Chem, 9:201-206, 2017 Cited by PubMed: 28221352DOI: 10.1038/nchem.2660 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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