5FLF
DISEASE LINKED MUTATION IN FGFR
Summary for 5FLF
Entry DOI | 10.2210/pdb5flf/pdb |
Descriptor | FIBROBLAST GROWTH FACTOR RECEPTOR 1, SULFATE ION, ACETATE ION, ... (6 entities in total) |
Functional Keywords | transferase, auto-activating, cancer, growth factor, receptor, mutation; |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 5 |
Total formula weight | 177743.93 |
Authors | Thiyagarajan, N.,Bunney, T.D.,Katan, M. (deposition date: 2015-10-26, release date: 2016-03-30, Last modification date: 2024-01-10) |
Primary citation | Patani, H.,Bunney, T.D.,Thiyagarajan, N.,Norman, R.A.,Ogg, D.,Breed, J.,Ashford, P.,Potterton, A.,Edwards, M.,Williams, S.V.,Thomson, G.S.,Pang, C.S.,Knowles, M.A.,Breeze, A.L.,Orengo, C.,Phillips, C.,Katan, M. Landscape of Activating Cancer Mutations in Fgfr Kinases and Their Differential Responses to Inhibitors in Clinical Use. Oncotarget, 7:24252-, 2016 Cited by PubMed: 26992226DOI: 10.18632/ONCOTARGET.8132 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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