5FLF
DISEASE LINKED MUTATION IN FGFR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | FIBROBLAST GROWTH FACTOR RECEPTOR 1 | polymer | 310 | 35208.5 | 5 | UniProt (P11362) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, BFGFR, BFGF-R-1, FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR |
| 2 | F, H, J, M, N... (A, B, C, D, E) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 3 | G (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | I, L, U, V, W (B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | K, R, S, T (C, D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 6 | AA, BA, CA, Y, Z (C, D, E, A, B) | water | water | 18.0 | 364 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Met 456 | - | expression tag |
| Val 457 | - | expression tag |
| Ala 488 | Cys 488 | conflict |
| Ser 584 | Cys 584 | conflict |
| Gly 675 | Arg 675 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 176042.4 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1701.6 | |
| All* | Total formula weight | 177743.9 |
