Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FLF

DISEASE LINKED MUTATION IN FGFR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005007	molecular_function	fibroblast growth factor receptor activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005007	molecular_function	fibroblast growth factor receptor activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0005007	molecular_function	fibroblast growth factor receptor activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 1762

Chain	Residue
D	THR726
D	ASN727
D	GLU728
D	HOH2085
E	LYS617

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1764

Chain	Residue
D	SER699
D	HOH2088
B	THR726
B	ASN727
D	ARG577
D	GLY698

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 1765

Chain	Residue
D	ARG570

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1763

Chain	Residue
A	ARG622
A	ARG646
A	TYR654
A	ARG661

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1764

Chain	Residue
C	ARG622
C	ARG646
C	TYR654
C	LYS656
C	THR657
C	ARG661

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1765

Chain	Residue
B	ARG622
B	ARG646
B	TYR654
B	LYS656
B	ARG661
B	HOH2048

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1766

Chain	Residue
D	LYS523
D	ARG622
D	LEU644
D	ARG646
D	TYR654
D	LYS656

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1767

Chain	Residue
D	ASP735
D	HIS738
D	GLN743
E	LYS542
E	TYR605

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 1768

Chain	Residue
D	LYS566
D	ARG576

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PGE C 1765

Chain	Residue
C	ALA615
C	HIS679
C	GLN680
C	VAL683
C	PRO741
C	ARG744
C	PRO745
C	THR746
C	PHE747
C	LYS748

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PGE D 1769

Chain	Residue
B	HIS649
D	SER530

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE D 1770

Chain	Residue
D	THR746
D	PHE747
D	LYS748
D	GLN749
D	CL1772
D	HOH2045

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE D 1771

Chain	Residue
D	ARG470
D	TRP471
D	GLU472
D	LEU500

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 1766

Chain	Residue
B	PHE747

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 1772

Chain	Residue
D	PHE747
D	PGE1770

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 1773

Chain	Residue
D	LYS514

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 1774

Chain	Residue
D	TYR701
D	HIS717

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 1764

Chain	Residue
A	THR726
A	ASN727

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	54
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)