5FJV

Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly

Summary for 5FJV

Entry DOI	10.2210/pdb5fjv/pdb
Descriptor	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-2, EPIBATIDINE (2 entities in total)
Functional Keywords	acetylcholine-binding protein, nachr, extracellular domain, nicotinic acetylcholine receptor, epibatidine, agonist, alpha2
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein: Q15822
Total number of polymer chains	5
Total formula weight	126495.43
Authors	Giastas, P.,Kouvatsos, N.,Chroni-Tzartou, D.,Tzartos, S.J. (deposition date: 2015-10-13, release date: 2016-08-10, Last modification date: 2024-01-10)
Primary citation	Kouvatsos, N.,Giastas, P.,Chroni-Tzartou, D.,Poulopoulou, C.,Tzartos, S.J. Crystal Structure of a Human Neuronal Nachr Extracellular Domain in Pentameric Assembly: Ligand-Bound Alpah2 Homopentamer. Proc.Natl.Acad.Sci.USA, 113:9635-, 2016 Cited by PubMed: 27493220 DOI: 10.1073/PNAS.1602619113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation