5FJV

Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPJ A 300

Chain	Residue
A	TYR122
A	TRP178
A	THR179
A	TYR219
A	TYR226
B	TRP84
B	LYS136
B	HIS146
B	VAL148

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPJ B 300

Chain	Residue
B	TYR122
B	TRP178
B	THR179
B	TYR219
B	CYS222
B	TYR226
C	TRP84
C	LYS136
C	HIS146
C	VAL148

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EPJ C 300

Chain	Residue
C	TYR122
C	TRP178
C	THR179
C	TYR226
D	TRP84
D	LYS136
D	HIS138
D	HIS146
D	VAL148

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EPJ D 300

Chain	Residue
D	TYR122
D	TRP178
D	THR179
D	TYR219
D	TYR226
E	LYS136
E	HIS146
E	VAL148

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EPJ E 300

Chain	Residue
A	TRP84
A	LYS136
A	HIS146
A	VAL148
E	TYR122
E	TRP178
E	THR179
E	TYR219
E	CYS222
E	TYR226

---

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsIdVtfFPfDqqnC

Chain	Residue	Details
A	CYS157-CYS171

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN53
D	ASN53
D	ASN103
D	ASN209
E	ASN53
E	ASN103
E	ASN209
A	ASN103
A	ASN209
B	ASN53
B	ASN103
B	ASN209
C	ASN53
C	ASN103
C	ASN209

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