5FI0

Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1

5FI0 の概要

• エントリーDOI: 10.2210/pdb5fi0/pdb
• 関連するPDBエントリー: 5FI1
• 分子名称: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: dbl homology domain, pleckstrin homology domain, beta sandwich, small gtpase, protein binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 259892.12

構造登録者

Cash, J.N.,Tesmer, J.J.G. (登録日: 2015-12-22, 公開日: 2016-04-20, 最終更新日: 2023-09-27)

• 主引用文献: Cash, J.N.,Davis, E.M.,Tesmer, J.J.; Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.; Structure, 24:730-740, 2016; PubMed: 27150042; DOI: 10.1016/j.str.2016.02.022

実験手法

X-RAY DIFFRACTION (3.282 Å)