5FHQ

Crystal structure of (WT) Rat Catechol-O-Methyltransferase in complex with AdoMet and 3,5-dinitrocatechol (DNC)

Summary for 5FHQ

Entry DOI	10.2210/pdb5fhq/pdb
Descriptor	Catechol O-methyltransferase, S-ADENOSYLMETHIONINE, 3,5-DINITROCATECHOL, ... (5 entities in total)
Functional Keywords	methyltransferase regioselectivity, transferase
Biological source	Rattus norvegicus (Norway Rat)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
Total number of polymer chains	1
Total formula weight	24604.38
Authors	Levy, C. (deposition date: 2015-12-22, release date: 2016-02-03, Last modification date: 2024-01-10)
Primary citation	Law, B.J.,Bennett, M.R.,Thompson, M.L.,Levy, C.,Shepherd, S.A.,Leys, D.,Micklefield, J. Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase. Angew.Chem.Int.Ed.Engl., 55:2683-2687, 2016 Cited by PubMed: 26797714 DOI: 10.1002/anie.201508287 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation