5FHC

Crystal Structure of Protective Human Antibodies 100 and 114 in Complex with Ebola Virus Fusion Glycoprotein (GP)

5FHC の概要

• エントリーDOI: 10.2210/pdb5fhc/pdb
• 関連するPDBエントリー: 5FHA 5FHB
• 分子名称: Envelope glycoprotein, Envelope glycoprotein,Envelope glycoprotein, Antibody 100 Fab heavy chain, ... (6 entities in total)
• 機能のキーワード: ig domain, fab, immune system, fusion, ebola virus, glycoprotein, gp, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Zaire ebolavirus (strain Mayinga-76) (ZEBOV); 詳細
• 細胞内の位置: GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320 Q05320
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 139919.80

構造登録者

Gilman, M.S.A.,McLellan, J.S. (登録日: 2015-12-21, 公開日: 2016-03-16, 最終更新日: 2016-03-30)

• 主引用文献: Misasi, J.,Gilman, M.S.,Kanekiyo, M.,Gui, M.,Cagigi, A.,Mulangu, S.,Corti, D.,Ledgerwood, J.E.,Lanzavecchia, A.,Cunningham, J.,Muyembe-Tamfun, J.J.,Baxa, U.,Graham, B.S.,Xiang, Y.,Sullivan, N.J.,McLellan, J.S.; Structural and molecular basis for Ebola virus neutralization by protective human antibodies.; Science, 351:1343-1346, 2016; PubMed: 26917592; DOI: 10.1126/science.aad6117

実験手法

X-RAY DIFFRACTION (6.704 Å)