5FG6

Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe

Summary for 5FG6

• Entry DOI: 10.2210/pdb5fg6/pdb
• Descriptor: Bromodomain-containing protein 1, 1,2-ETHANEDIOL, 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide, ... (6 entities in total)
• Functional Keywords: moz-morf complex, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : O95696
• Total number of polymer chains: 1
• Total formula weight: 15704.27

Authors

Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Savitsky, P.,Chaikuad, A.,Fedorov, O.,Nunez-Alonso, G.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S. (deposition date: 2015-12-20, release date: 2016-02-03, Last modification date: 2024-01-10)

• Primary citation: Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Savitsky, P.,Chaikuad, A.,Fedorov, O.,Nunez-Alonso, G.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S.; Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.1 Å)