5FDR

Mcl-1 complexed with small molecule inhibitor

Summary for 5FDR

Entry DOI	10.2210/pdb5fdr/pdb
Related	4HW2
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, 5-[[6-chloranyl-3-[3-(4-chloranyl-3,5-dimethyl-phenoxy)propyl]-7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-1~{H}-indol-2-yl]carbonylsulfamoyl]furan-2-carboxylic acid (2 entities in total)
Functional Keywords	mcl-1, inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	74499.62
Authors	Zhao, B. (deposition date: 2015-12-16, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citation	Pelz, N.F.,Bian, Z.,Zhao, B.,Shaw, S.,Tarr, J.C.,Belmar, J.,Gregg, C.,Camper, D.V.,Goodwin, C.M.,Arnold, A.L.,Sensintaffar, J.L.,Friberg, A.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W. Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. J.Med.Chem., 59:2054-2066, 2016 Cited by PubMed: 26878343 DOI: 10.1021/acs.jmedchem.5b01660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation