5FC4

Mcl-1 complexed with small molecule inhibitor

Summary for 5FC4

• Entry DOI: 10.2210/pdb5fc4/pdb
• Related: 4ZBF
• Descriptor: Induced myeloid leukemia cell differentiation protein Mcl-1, 6-chloranyl-~{N}-methylsulfonyl-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxamide, 2-[5-[1,1,2,2-tetrakis(fluoranyl)ethyl]-1~{H}-pyrazol-3-yl]phenol, ... (4 entities in total)
• Functional Keywords: mcl-1, inhibitor, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 18134.40

Authors

Zhao, B. (deposition date: 2015-12-14, release date: 2016-03-02, Last modification date: 2023-09-27)

• Primary citation: Pelz, N.F.,Bian, Z.,Zhao, B.,Shaw, S.,Tarr, J.C.,Belmar, J.,Gregg, C.,Camper, D.V.,Goodwin, C.M.,Arnold, A.L.,Sensintaffar, J.L.,Friberg, A.,Rossanese, O.W.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.; Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.; J.Med.Chem., 59:2054-2066, 2016; PubMed: 26878343; DOI: 10.1021/acs.jmedchem.5b01660

Experimental method

X-RAY DIFFRACTION (1.5 Å)