5FC4
Mcl-1 complexed with small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 150 | 16960.3 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | B, C (A) | 6-chloranyl-~{N}-methylsulfonyl-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxamide | non-polymer | 456.9 | 2 | Chemie (5WL) | |||
| 3 | D (A) | 2-[5-[1,1,2,2-tetrakis(fluoranyl)ethyl]-1~{H}-pyrazol-3-yl]phenol | non-polymer | 260.2 | 1 | Chemie (5WK) | |||
| 4 | E (A) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
A: 172 - 320 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 171 | - | expression tag |
| Ala 202 | Ser 202 | conflict |
| Ala 238 | Lys 238 | conflict |
| Ala 288 | Glu 288 | conflict |
| Ala 308 | Lys 308 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16960.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1174.1 | |
| All* | Total formula weight | 18134.4 |
