5F6H

Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque

Summary for 5F6H

• Entry DOI: 10.2210/pdb5f6h/pdb
• Related: 5F6I 5F6J
• Descriptor: DH427 Antibody Light Chain, DH427 Antibody Heavy Chain (3 entities in total)
• Functional Keywords: fab fragment, hiv-1, antibody, immune system
• Biological source: Macaca mulatta; More
• Total number of polymer chains: 8
• Total formula weight: 188416.97

Authors

Fera, D.,Harrison, S.C. (deposition date: 2015-12-06, release date: 2016-01-13, Last modification date: 2023-09-27)

• Primary citation: Bradley, T.,Fera, D.,Bhiman, J.,Eslamizar, L.,Lu, X.,Anasti, K.,Zhang, R.,Sutherland, L.L.,Scearce, R.M.,Bowman, C.M.,Stolarchuk, C.,Lloyd, K.E.,Parks, R.,Eaton, A.,Foulger, A.,Nie, X.,Karim, S.S.,Barnett, S.,Kelsoe, G.,Kepler, T.B.,Alam, S.M.,Montefiori, D.C.,Moody, M.A.,Liao, H.X.,Morris, L.,Santra, S.,Harrison, S.C.,Haynes, B.F.; Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.; Cell Rep, 14:43-54, 2016; PubMed: 26725118; DOI: 10.1016/j.celrep.2015.12.017

Experimental method

X-RAY DIFFRACTION (2.66 Å)