5F49

Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with malonyl-coenzyme A

Summary for 5F49

Entry DOI	10.2210/pdb5f49/pdb
Related	5F46 5F47 5F48 5U08
Descriptor	aminoglycoside acetyltransferase meta-AAC0020, COENZYME A, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	gnat fold, gcn5-n-acetyltransferase fold, acetyltransferase, aminoglycoside, antibiotic resistance, metagenome, soil, coenzyme a, structural genomics, center for structural genomics of infectious diseases, csgid, transferase
Biological source	uncultured bacterium
Total number of polymer chains	4
Total formula weight	77630.66
Authors	Xu, Z.,Skarina, T.,Stogios, P.J.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2015-12-03, release date: 2015-12-16, Last modification date: 2024-03-06)
Primary citation	Xu, Z.,Stogios, P.J.,Quaile, A.T.,Forsberg, K.J.,Patel, S.,Skarina, T.,Houliston, S.,Arrowsmith, C.,Dantas, G.,Savchenko, A. Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes. ACS Infect Dis, 3:653-665, 2017 Cited by PubMed: 28756664 DOI: 10.1021/acsinfecdis.7b00068 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation