5F49
Crystal structure of an aminoglycoside acetyltransferase meta-AAC0020 from an uncultured soil metagenomic sample in complex with malonyl-coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019809 | molecular_function | spermidine binding |
| A | 0032918 | biological_process | spermidine acetylation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008080 | molecular_function | N-acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019809 | molecular_function | spermidine binding |
| B | 0032918 | biological_process | spermidine acetylation |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008080 | molecular_function | N-acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0019809 | molecular_function | spermidine binding |
| C | 0032918 | biological_process | spermidine acetylation |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008080 | molecular_function | N-acetyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0019809 | molecular_function | spermidine binding |
| D | 0032918 | biological_process | spermidine acetylation |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue COA A 201 |
| Chain | Residue |
| A | LEU92 |
| A | LYS105 |
| A | ASP131 |
| A | TYR133 |
| A | ASP136 |
| A | PHE137 |
| A | SER140 |
| A | MG204 |
| A | HOH301 |
| A | HOH315 |
| A | HOH352 |
| A | ALA93 |
| A | HOH371 |
| A | HOH379 |
| B | GLU18 |
| B | HOH380 |
| A | VAL94 |
| A | GLN99 |
| A | ARG100 |
| A | GLN101 |
| A | GLY102 |
| A | ILE103 |
| A | GLY104 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | GLU18 |
| A | ASN53 |
| A | ASN55 |
| A | HOH389 |
| A | HOH395 |
| A | HOH398 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | ASN39 |
| A | HOH378 |
| A | HOH424 |
| C | HOH314 |
| D | HOH304 |
| D | HOH316 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 204 |
| Chain | Residue |
| A | COA201 |
| A | HOH379 |
| B | GLU18 |
| B | ASN53 |
| B | HOH380 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | binding site for residue MLC B 201 |
| Chain | Residue |
| A | ASN19 |
| A | PRO22 |
| B | VAL34 |
| B | PHE35 |
| B | ASP91 |
| B | LEU92 |
| B | ALA93 |
| B | VAL94 |
| B | GLN99 |
| B | ARG100 |
| B | GLN101 |
| B | GLY102 |
| B | ILE103 |
| B | GLY104 |
| B | LYS105 |
| B | ASP128 |
| B | TYR133 |
| B | ASP136 |
| B | PHE137 |
| B | SER140 |
| B | HOH310 |
| B | HOH316 |
| B | HOH320 |
| B | HOH349 |
| B | HOH371 |
| B | HOH377 |
| B | HOH379 |
| B | HOH384 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| A | HOH350 |
| B | GLU14 |
| B | ASP20 |
| B | HOH338 |
| B | HOH369 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 203 |
| Chain | Residue |
| A | ASP44 |
| A | HOH304 |
| A | HOH333 |
| B | GLU83 |
| B | HOH333 |
| C | PHE40 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | binding site for residue MLC C 201 |
| Chain | Residue |
| C | HOH306 |
| C | HOH311 |
| C | HOH339 |
| C | HOH358 |
| D | GLU18 |
| D | HOH305 |
| C | VAL34 |
| C | PHE35 |
| C | TYR90 |
| C | ASP91 |
| C | LEU92 |
| C | ALA93 |
| C | VAL94 |
| C | GLN99 |
| C | ARG100 |
| C | GLN101 |
| C | GLY102 |
| C | ILE103 |
| C | GLY104 |
| C | LYS105 |
| C | TYR133 |
| C | ASP136 |
| C | PHE137 |
| C | TYR138 |
| C | SER140 |
| C | MG202 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 202 |
| Chain | Residue |
| C | MLC201 |
| C | HOH306 |
| C | HOH311 |
| D | GLU18 |
| D | ASN53 |
| D | HOH305 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue MLC D 201 |
| Chain | Residue |
| D | VAL34 |
| D | PHE35 |
| D | TYR90 |
| D | ASP91 |
| D | LEU92 |
| D | VAL94 |
| D | GLN99 |
| D | ARG100 |
| D | GLN101 |
| D | GLY102 |
| D | ILE103 |
| D | GLY104 |
| D | LYS105 |
| D | TYR133 |
| D | PHE137 |
| D | TYR138 |
| D | SER140 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 202 |
| Chain | Residue |
| D | GLU14 |
| D | ASP20 |
| D | HOH336 |
| D | HOH338 |
| D | HOH345 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 203 |
| Chain | Residue |
| A | PHE40 |
| C | ASP44 |
| C | HOH303 |
| C | HOH325 |
| D | GLU83 |
| D | HOH307 |
