5F1H

Crystal structure of the BRD9 bromodamian in complex with BI-9564.

Summary for 5F1H

Entry DOI	10.2210/pdb5f1h/pdb
Descriptor	Bromodomain-containing protein 9, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one (3 entities in total)
Functional Keywords	bromodomain, inhibitor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29206.36
Authors	Bader, G.,Martin, L.J.,Steurer, S.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2015-11-30, release date: 2016-03-09, Last modification date: 2024-01-10)
Primary citation	Martin, L.J.,Koegl, M.,Bader, G.,Cockcroft, X.L.,Fedorov, O.,Fiegen, D.,Gerstberger, T.,Hofmann, M.H.,Hohmann, A.F.,Kessler, D.,Knapp, S.,Knesl, P.,Kornigg, S.,Muller, S.,Nar, H.,Rogers, C.,Rumpel, K.,Schaaf, O.,Steurer, S.,Tallant, C.,Vakoc, C.R.,Zeeb, M.,Zoephel, A.,Pearson, M.,Boehmelt, G.,McConnell, D. Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J.Med.Chem., 59:4462-4475, 2016 Cited by PubMed: 26914985 DOI: 10.1021/acs.jmedchem.5b01865 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation