5F1A

The Crystal Structure of Salicylate Bound to Human Cyclooxygenase-2

5F1A の概要

• エントリーDOI: 10.2210/pdb5f1a/pdb
• 関連するPDBエントリー: 5F19
• 分子名称: Prostaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: membrane protein, monotopic, cyclooxygenase, cyclooxygenase-2, cox, pghs, salicylic acid, salicylate, inhibitor, complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 131672.34

構造登録者

Lucido, M.J.,Orlando, B.J.,Malkowski, M.G. (登録日: 2015-11-30, 公開日: 2016-03-16, 最終更新日: 2020-07-29)

• 主引用文献: Lucido, M.J.,Orlando, B.J.,Vecchio, A.J.,Malkowski, M.G.; Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.; Biochemistry, 55:1226-1238, 2016; PubMed: 26859324; DOI: 10.1021/acs.biochem.5b01378

実験手法

X-RAY DIFFRACTION (2.38 Å)