5EZD
Crystal structure of a Hepatocyte growth factor activator inhibitor-1 (HAI-1) fragment covering the PKD-like 'internal' domain and Kunitz domain 1
Summary for 5EZD
Entry DOI | 10.2210/pdb5ezd/pdb |
Descriptor | Kunitz-type protease inhibitor 1, POTASSIUM ION, ACETATE ION, ... (4 entities in total) |
Functional Keywords | transmembrane, multidomain, serine protease inhibitor, tertiary structure, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: O43278 |
Total number of polymer chains | 2 |
Total formula weight | 33765.88 |
Authors | Hong, Z.,Andreasen, P.A.,Morth, J.P.,Jensen, J.K. (deposition date: 2015-11-26, release date: 2016-05-18, Last modification date: 2024-01-10) |
Primary citation | Hong, Z.,De Meulemeester, L.,Jacobi, A.,Pedersen, J.S.,Morth, J.P.,Andreasen, P.A.,Jensen, J.K. Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN. J.Biol.Chem., 291:14340-14355, 2016 Cited by PubMed: 27189939DOI: 10.1074/jbc.M115.707240 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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