5EWJ
CRYSTAL STRUCTURE OF AMINO TERMINAL DOMAINS OF THE NMDA RECEPTOR SUBUNIT GLUN1 AND GLUN2B IN COMPLEX WITH IFENPRODIL
Summary for 5EWJ
Entry DOI | 10.2210/pdb5ewj/pdb |
Related | 5EWL 5EWM |
Descriptor | NMDA glutamate receptor subunit, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | glutamate receptor, allosteric modulator, glun2b antagonists, transport protein |
Biological source | Xenopus laevis (African clawed frog) More |
Total number of polymer chains | 4 |
Total formula weight | 173154.70 |
Authors | Pandit, J. (deposition date: 2015-11-20, release date: 2016-03-02, Last modification date: 2023-09-27) |
Primary citation | Stroebel, D.,Buhl, D.L.,Knafels, J.D.,Chanda, P.K.,Green, M.,Sciabola, S.,Mony, L.,Paoletti, P.,Pandit, J. A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists. Mol.Pharmacol., 89:541-551, 2016 Cited by PubMed: 26912815DOI: 10.1124/mol.115.103036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
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