5EW8

FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693

Summary for 5EW8

• Entry DOI: 10.2210/pdb5ew8/pdb
• Descriptor: Fibroblast growth factor receptor 1, SULFATE ION, ~{N}'-(3,5-dimethoxyphenyl)-~{N}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{N}-propan-2-yl-ethane-1,2-diamine, ... (4 entities in total)
• Functional Keywords: fgfr1 kinase inhibitor complex, kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362
• Total number of polymer chains: 2
• Total formula weight: 71451.96

Authors

Ogg, D.,Breed, J. (deposition date: 2015-11-20, release date: 2016-03-30, Last modification date: 2016-08-10)

• Primary citation: Patani, H.,Bunney, T.D.,Thiyagarajan, N.,Norman, R.A.,Ogg, D.,Breed, J.,Ashford, P.,Potterton, A.,Edwards, M.,Williams, S.V.,Thomson, G.S.,Pang, C.S.,Knowles, M.A.,Breeze, A.L.,Orengo, C.,Phillips, C.,Katan, M.; Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.; Oncotarget, 7:24252-24268, 2016; PubMed: 26992226; DOI: 10.18632/oncotarget.8132

Experimental method

X-RAY DIFFRACTION (1.63 Å)