5EW8

FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH JNJ-4275693

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 801

Chain	Residue
A	GLY539
A	LYS540
A	LYS618
A	HOH990
A	HOH1046
A	HOH1062

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 802

Chain	Residue
A	ASN659
A	ARG661
A	HOH950
A	HOH1005
A	ARG570
A	ARG627
A	THR657

---

site_id	AC3
Number of Residues	19
Details	binding site for residue 5SF A 803

Chain	Residue
A	LEU484
A	ALA512
A	LYS514
A	GLU531
A	MET535
A	ILE545
A	GLU562
A	TYR563
A	ALA564
A	GLY567
A	ARG627
A	ASN628
A	LEU630
A	ALA640
A	ASP641
A	PHE642
A	HOH934
A	HOH1042
A	HOH1060

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 B 801

Chain	Residue
B	ARG570
B	ARG627
B	THR657
B	ASN659
B	ARG661
B	HOH964
B	HOH1004

---

site_id	AC5
Number of Residues	18
Details	binding site for residue 5SF B 802

Chain	Residue
B	LEU484
B	ALA512
B	LYS514
B	GLU531
B	MET535
B	ILE545
B	GLU562
B	TYR563
B	ALA564
B	GLY567
B	ARG627
B	ASN628
B	LEU630
B	ALA640
B	ASP641
B	PHE642
B	HOH1011
B	HOH1029

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---