5EU7

Crystal structure of HIV-1 integrase catalytic core in complex with Fab

5EU7 の概要

• エントリーDOI: 10.2210/pdb5eu7/pdb
• 分子名称: Integrase, FAB Heavy Chain, FAB light chain, ... (4 entities in total)
• 機能のキーワード: integrase, fab, hiv, viral protein
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 129823.00

構造登録者

Galilee, M.,Griner, S.L.,Stroud, R.M.,Alian, A. (登録日: 2015-11-18, 公開日: 2016-09-28, 最終更新日: 2024-01-10)

• 主引用文献: Galilee, M.,Britan-Rosich, E.,Griner, S.L.,Uysal, S.,Baumgartel, V.,Lamb, D.C.,Kossiakoff, A.A.,Kotler, M.,Stroud, R.M.,Marx, A.,Alian, A.; The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.; Structure, 24:1936-1946, 2016; PubMed: 27692964; DOI: 10.1016/j.str.2016.08.015

実験手法

X-RAY DIFFRACTION (2.64 Å)