5ENN

The crystal structure of Human VPS34 in complex with a selective and potent inhibitor

Summary for 5ENN

• Entry DOI: 10.2210/pdb5enn/pdb
• Related: 4PH4
• Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3, 1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methyl-propan-2-ol, SODIUM ION, ... (6 entities in total)
• Functional Keywords: vps34, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Midbody : Q8NEB9
• Total number of polymer chains: 2
• Total formula weight: 144707.17

Authors

Kearney, E.P. (deposition date: 2015-11-09, release date: 2016-11-16, Last modification date: 2024-03-06)

• Primary citation: Kearney, E.P.; Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)