5ENN
The crystal structure of Human VPS34 in complex with a selective and potent inhibitor
Summary for 5ENN
Entry DOI | 10.2210/pdb5enn/pdb |
Related | 4PH4 |
Descriptor | Phosphatidylinositol 3-kinase catalytic subunit type 3, 1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methyl-propan-2-ol, SODIUM ION, ... (6 entities in total) |
Functional Keywords | vps34, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Midbody : Q8NEB9 |
Total number of polymer chains | 2 |
Total formula weight | 144707.17 |
Authors | Kearney, E.P. (deposition date: 2015-11-09, release date: 2016-11-16, Last modification date: 2024-03-06) |
Primary citation | Kearney, E.P. Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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