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5ENN

The crystal structure of Human VPS34 in complex with a selective and potent inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0016301molecular_functionkinase activity
B0016303molecular_function1-phosphatidylinositol-3-kinase activity
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue 5QS A 901
ChainResidue
APHE612
ASER687
ALEU750
AILE760
AASP761
AHOH1002
AHOH1057
AHOH1077
ASER614
AILE634
ALYS636
ATYR670
AMET682
AGLN683
APHE684
AILE685

site_idAC2
Number of Residues1
Detailsbinding site for residue NA A 902
ChainResidue
APRO669

site_idAC3
Number of Residues14
Detailsbinding site for residue 5QS B 901
ChainResidue
BPHE612
BILE634
BLYS636
BMET682
BGLN683
BPHE684
BILE685
BSER687
BLEU750
BILE760
BASP761
BHOH1001
BHOH1032
BHOH1091

site_idAC4
Number of Residues6
Detailsbinding site for residue GOL B 903
ChainResidue
BTHR668
BPRO669
BGLN683
BILE685
BLYS756
BHOH1039

site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 B 904
ChainResidue
BTYR494
BSER525
BARG539
BHOH1082

Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ
ChainResidueDetails
APHE635-GLN649

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN
ChainResidueDetails
ASER728-ASN748

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PDB entries from 2024-06-12

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