5EKN
Crystal structure of MAPK13 complex with inhibitor
Summary for 5EKN
| Entry DOI | 10.2210/pdb5ekn/pdb |
| Related | 4EYJ 4EYM 4MYG 4YNO 5EKO |
| Descriptor | Mitogen-activated protein kinase 13, 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-ylsulfanyl)phenyl]urea (3 entities in total) |
| Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 43015.39 |
| Authors | Brett, T.J.,Miller, C.A.,Yurtsever, Z. (deposition date: 2015-11-03, release date: 2016-07-06, Last modification date: 2023-09-27) |
| Primary citation | Yurtsever, Z.,Patel, D.A.,Kober, D.L.,Su, A.,Miller, C.A.,Romero, A.G.,Holtzman, M.J.,Brett, T.J. First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes. Biochim.Biophys.Acta, 1860:2335-2344, 2016 Cited by PubMed: 27369736DOI: 10.1016/j.bbagen.2016.06.023 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.594 Å) |
Structure validation
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