5EKN

Crystal structure of MAPK13 complex with inhibitor

5EKN の概要

• エントリーDOI: 10.2210/pdb5ekn/pdb
• 関連するPDBエントリー: 4EYJ 4EYM 4MYG 4YNO 5EKO
• 分子名称: Mitogen-activated protein kinase 13, 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-ylsulfanyl)phenyl]urea (3 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43015.39

構造登録者

Brett, T.J.,Miller, C.A.,Yurtsever, Z. (登録日: 2015-11-03, 公開日: 2016-07-06, 最終更新日: 2023-09-27)

主引用文献

Yurtsever, Z.,Patel, D.A.,Kober, D.L.,Su, A.,Miller, C.A.,Romero, A.G.,Holtzman, M.J.,Brett, T.J.
First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Biochim.Biophys.Acta, 1860:2335-2344, 2016

PubMed Abstract: P38 MAP kinases are centrally involved in mediating extracellular signaling in various diseases. While much attention has previously been focused on the ubiquitously expressed family member MAPK14 (p38α), recent studies indicate that family members such as MAPK13 (p38δ) display a more selective cellular and tissue expression and might therefore represent a specific kinase to target in certain diseases.

PubMed: 27369736
DOI: 10.1016/j.bbagen.2016.06.023

実験手法

X-RAY DIFFRACTION (2.594 Å)