5EGO
HOXB13-MEIS1 heterodimer bound to methylated DNA
Summary for 5EGO
Entry DOI | 10.2210/pdb5ego/pdb |
Descriptor | Homeobox protein Meis1, DNA (5'-D(P*GP*TP*TP*GP*AP*CP*AP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*TP*GP*TP*CP*AP*AP*C)-3'), ... (5 entities in total) |
Functional Keywords | transcription factor, heterodimer, complex, bound to dna, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : O00470 Q92826 |
Total number of polymer chains | 4 |
Total formula weight | 25456.13 |
Authors | Morgunova, E.,Yin, Y.,Jolma, A.,Popov, A.,Taipale, J. (deposition date: 2015-10-27, release date: 2016-11-09, Last modification date: 2024-01-10) |
Primary citation | Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356:-, 2017 Cited by PubMed: 28473536DOI: 10.1126/science.aaj2239 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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