5EEG

Crystal structure of carminomycin-4-O-methyltransferase DnrK in complex with tetrazole-SAH

Summary for 5EEG

• Entry DOI: 10.2210/pdb5eeg/pdb
• Related: 5EEH
• Descriptor: Carminomycin 4-O-methyltransferase DnrK, (2~{R},3~{R},4~{S},5~{S})-2-(6-aminopurin-9-yl)-5-[[(3~{S})-3-azanyl-3-(1~{H}-1,2,3,4-tetrazol-5-yl)propyl]sulfanylmethyl]oxolane-3,4-diol (3 entities in total)
• Functional Keywords: unnatural substrate, structural genomics, psi-biology, protein structure initiative, enzyme discovery for natural product biosynthesis, natpro, transferase
• Biological source: Streptomyces peucetius
• Total number of polymer chains: 2
• Total formula weight: 82817.69

Authors

Wang, F.,Singh, S.,Thorson, J.S.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2015-10-22, release date: 2015-12-23, Last modification date: 2023-09-27)

• Primary citation: Huber, T.D.,Wang, F.,Singh, S.,Johnson, B.R.,Zhang, J.,Sunkara, M.,Van Lanen, S.G.,Morris, A.J.,Phillips, G.N.,Thorson, J.S.; Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways.; Acs Chem.Biol., 11:2484-2491, 2016; PubMed: 27351335; DOI: 10.1021/acschembio.6b00348

Experimental method

X-RAY DIFFRACTION (2.255 Å)