5ECG
Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)
Summary for 5ECG
Entry DOI | 10.2210/pdb5ecg/pdb |
Descriptor | Cellular tumor antigen p53, Tumor suppressor p53-binding protein 1, SEP-GLN-GLU-TYR, ... (5 entities in total) |
Functional Keywords | dna repair, nhej, h2ax, brct, antitumor protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 Nucleus: Q12888 |
Total number of polymer chains | 6 |
Total formula weight | 110952.06 |
Authors | Day, M.,Oliver, A.W.,Pearl, L.H. (deposition date: 2015-10-20, release date: 2015-12-16, Last modification date: 2024-01-10) |
Primary citation | Baldock, R.A.,Day, M.,Wilkinson, O.J.,Cloney, R.,Jeggo, P.A.,Oliver, A.W.,Watts, F.Z.,Pearl, L.H. ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX. Cell Rep, 13:2081-2089, 2015 Cited by PubMed: 26628370DOI: 10.1016/j.celrep.2015.10.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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