5EA5

Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein

5EA5 の概要

• エントリーDOI: 10.2210/pdb5ea5/pdb
• 関連するPDBエントリー: 4MMU 5EA3 5EA4 5EA6 5EA7 5EA8
• 分子名称: Fusion glycoprotein F0, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, ... (5 entities in total)
• 機能のキーワード: class i viral fusion protein, fusion, respiratory syncytial virus, prefusion, viral protein, fusion inhibitor, cell invasion-inhibitor complex, cell invasion/inhibitor
• 由来する生物種: Human respiratory syncytial virus A (strain A2)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64230.50

構造登録者

Battles, M.B.,McLellan, J.S.,Arnoult, E.,Roymans, D.,Langedijk, J.P. (登録日: 2015-10-15, 公開日: 2015-12-09, 最終更新日: 2023-09-27)

• 主引用文献: Battles, M.B.,Langedijk, J.P.,Furmanova-Hollenstein, P.,Chaiwatpongsakorn, S.,Costello, H.M.,Kwanten, L.,Vranckx, L.,Vink, P.,Jaensch, S.,Jonckers, T.H.,Koul, A.,Arnoult, E.,Peeples, M.E.,Roymans, D.,McLellan, J.S.; Molecular mechanism of respiratory syncytial virus fusion inhibitors.; Nat.Chem.Biol., 12:87-93, 2016; PubMed: 26641933; DOI: 10.1038/nchembio.1982

実験手法

X-RAY DIFFRACTION (3.05 Å)