5E91

TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH 3-AMINO-6-[4-(2- HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL] PYRAZINE-2-CARBOXAMIDE

Summary for 5E91

• Entry DOI: 10.2210/pdb5e91/pdb
• Related: 5E8S 5E8T 5E8U 5E8V 5E8W 5E8X 5E8Y 5E8Z 5E90 5E92
• Descriptor: TGF-beta receptor type-2, 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide (3 entities in total)
• Functional Keywords: kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P37173
• Total number of polymer chains: 1
• Total formula weight: 36261.14

Authors

Sheriff, S. (deposition date: 2015-10-14, release date: 2016-05-11, Last modification date: 2023-09-27)

• Primary citation: Tebben, A.J.,Ruzanov, M.,Gao, M.,Xie, D.,Kiefer, S.E.,Yan, C.,Newitt, J.A.,Zhang, L.,Kim, K.,Lu, H.,Kopcho, L.M.,Sheriff, S.; Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity.; Acta Crystallogr D Struct Biol, 72:658-674, 2016; PubMed: 27139629; DOI: 10.1107/S2059798316003624

Experimental method

X-RAY DIFFRACTION (2.42 Å)