5E91
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH 3-AMINO-6-[4-(2- HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL] PYRAZINE-2-CARBOXAMIDE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | TGF-beta receptor type-2 | polymer | 316 | 35840.7 | 1 | UniProt (P37173) Pfam (PF07714) In PDB | Homo sapiens (Human) | TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II |
2 | A | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | non-polymer | 420.5 | 1 | Chemie (5L4) | |||
3 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 237 - 549 (UniProt: P37173)
PDB | External Database | Details |
---|---|---|
Gly 234 | - | expression tag |
His 235 | - | expression tag |
Met 236 | - | expression tag |
Ala 431 | Glu 431 | engineered mutation |
Ala 433 | Arg 433 | engineered mutation |
Ala 485 | Glu 485 | engineered mutation |
Ala 488 | Lys 488 | engineered mutation |
Ala 493 | Arg 493 | engineered mutation |
Ala 495 | Arg 495 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35840.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 420.5 | |
All* | Total formula weight | 36261.1 |