5DWU

Beta common receptor in complex with a Fab

Summary for 5DWU

• Entry DOI: 10.2210/pdb5dwu/pdb
• Descriptor: Cytokine receptor common subunit beta, Fab - Heavy Chain, Fab - Light Chain, ... (5 entities in total)
• Functional Keywords: fab complex, antigen recognition, therapeutic antibody, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 96608.93

Authors

Dhagat, U.,Parker, M.W. (deposition date: 2015-09-23, release date: 2015-12-30, Last modification date: 2020-07-29)

• Primary citation: Panousis, C.,Dhagat, U.,Edwards, K.M.,Rayzman, V.,Hardy, M.P.,Braley, H.,Gauvreau, G.M.,Hercus, T.R.,Smith, S.,Sehmi, R.,McMillan, L.,Dottore, M.,McClure, B.J.,Fabri, L.J.,Vairo, G.,Lopez, A.F.,Parker, M.W.,Nash, A.D.,Wilson, N.J.,Wilson, M.J.,Owczarek, C.M.; CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors.; Mabs, 8:436-453, 2016; PubMed: 26651396; DOI: 10.1080/19420862.2015.1119352

Experimental method

X-RAY DIFFRACTION (3.97 Å)