5DR2

Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122

Summary for 5DR2

Entry DOI	10.2210/pdb5dr2/pdb
Descriptor	Aurora kinase A, 2-(3-bromophenyl)quinoline-4-carboxylic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	aurora a kinase, mitotic kinase, ppi, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32667.17
Authors	Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,McKenzie, G.J.,Huggins, D.J.,Stockwell, S.,Stokes, J.A.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,Venkitaraman, A.R. (deposition date: 2015-09-15, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citation	Janecek, M.,Rossmann, M.,Sharma, P.,Emery, A.,Huggins, D.J.,Stockwell, S.R.,Stokes, J.E.,Tan, Y.S.,Almeida, E.G.,Hardwick, B.,Narvaez, A.J.,Hyvonen, M.,Spring, D.R.,McKenzie, G.J.,Venkitaraman, A.R. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6:28528-28528, 2016 Cited by PubMed: 27339427 DOI: 10.1038/srep28528 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation