5DKP

Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556.

5DKP の概要

• エントリーDOI: 10.2210/pdb5dkp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000503
• 分子名称: ATP-dependent Clp protease proteolytic subunit, agonist ADEP A54556, POTASSIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, agonist, degradation, antimicrobial, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Neisseria meningitidis serogroup B (strain MC58); 詳細
• タンパク質・核酸の鎖数: 56
• 化学式量合計: 663700.30

構造登録者

Goodreid, J.D.,Janetzko, J.,Santa Maria Jr., J.P.,Wong, K.,Leung, E.,Eger, B.T.,Bryson, S.,Pai, E.F.,Gray-Owen, S.D.,Walker, S.,Houry, W.A.,Batey, R.A. (登録日: 2015-09-03, 公開日: 2016-01-27, 最終更新日: 2023-11-15)

• 主引用文献: Goodreid, J.D.,Janetzko, J.,Santa Maria, J.P.,Wong, K.S.,Leung, E.,Eger, B.T.,Bryson, S.,Pai, E.F.,Gray-Owen, S.D.,Walker, S.,Houry, W.A.,Batey, R.A.; Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity.; J.Med.Chem., 59:624-646, 2016; PubMed: 26818454; DOI: 10.1021/acs.jmedchem.5b01451

実験手法

X-RAY DIFFRACTION (2.381 Å)