5DKJ

Yeast 20S proteasome in complex with octreotide-PI

Summary for 5DKJ

• Entry DOI: 10.2210/pdb5dkj/pdb
• Related: 1RYP 2F16
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, target delivery, proteasome, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 735007.85

Authors

Beck, P.,Cui, H.,Groll, M. (deposition date: 2015-09-03, release date: 2015-10-28, Last modification date: 2024-01-10)

• Primary citation: Beck, P.,Cui, H.,Hegemann, J.D.,Marahiel, M.A.,Kruger, A.,Groll, M.; Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.; Chemmedchem, 10:1969-1973, 2015; PubMed: 26471124; DOI: 10.1002/cmdc.201500449

Experimental method

X-RAY DIFFRACTION (2.8 Å)