5DKC
Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe
Summary for 5DKC
Entry DOI | 10.2210/pdb5dkc/pdb |
Descriptor | Probable global transcription activator SNF2L2, ZINC ION, (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one, ... (4 entities in total) |
Functional Keywords | swi-snf complex, chromatin remodeling, brg associated factors (baf), transcription, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P51531 |
Total number of polymer chains | 1 |
Total formula weight | 14767.32 |
Authors | Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Fedorov, O.,Savitsky, P.,Nunez-Alonso, G.,Fonseca, M.,Krojer, T.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S. (deposition date: 2015-09-03, release date: 2015-10-14, Last modification date: 2024-01-10) |
Primary citation | Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Fedorov, O.,Savitsky, P.,Nunez-Alonso, G.,Fonseca, M.,Krojer, T.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S. Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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