5DJP
Crystal structure of human FPPS in complex with biaryl compound 5
Summary for 5DJP
Entry DOI | 10.2210/pdb5djp/pdb |
Related | 5DGN 5DIQ |
Descriptor | Farnesyl pyrophosphate synthase, 4-(naphthalen-1-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | transferase, isoprene biosynthesis, cholesterol biosynthesis |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40566.14 |
Authors | Rondeau, J.M.,Bourgier, E.,Lehmann, S. (deposition date: 2015-09-02, release date: 2015-09-30, Last modification date: 2024-05-08) |
Primary citation | Marzinzik, A.L.,Amstutz, R.,Bold, G.,Bourgier, E.,Cotesta, S.,Glickman, J.F.,Gotte, M.,Henry, C.,Lehmann, S.,Hartwieg, J.C.,Ofner, S.,Pelle, X.,Roddy, T.P.,Rondeau, J.M.,Stauffer, F.,Stout, S.J.,Widmer, A.,Zimmermann, J.,Zoller, T.,Jahnke, W. Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10:1884-1891, 2015 Cited by PubMed: 26381451DOI: 10.1002/cmdc.201500338 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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